What is net clinical benefit?
Net clinical benefit is a measure of the total value a treatment provides, considering both its positive outcomes and its potential harms. It reflects a holistic view of efficacy, safety, tolerability, and patient quality of life. It can be assessed through clinical trial data, real-world evidence, and health economic modeling.
Why is net clinical benefit important in pharmaceutical evaluation?
Demonstrating net clinical benefit is critical for regulatory approval, payer coverage, and clinical adoption. It supports benefit-risk assessments, treatment guidelines, and value-based pricing decisions. It also helps align product messaging with real-world stakeholder priorities.
