Line of therapy

Line of therapy refers to the sequence in which treatments are given to a patient, typically categorized as first-line, second-line, or third-line based on clinical guidelines or treatment history.

What is line of therapy?

Line of therapy defines the order in which medical treatments are administered for a condition. First-line therapy is the initial treatment used, while second- or third-line therapies are given if the disease progresses or if the patient does not respond. Treatment sequencing is influenced by clinical guidelines, disease stage, prior response, and patient characteristics.

Why is line of therapy important in clinical development and access strategy?

Positioning a product at the right line of therapy affects trial design, competitive landscape analysis, and market access planning. Earlier-line placement may lead to broader patient access and higher commercial value. Understanding treatment pathways helps tailor value messaging and payer discussions.

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